Stem cells are a type of biological cells that are found in the higher animals. They are undifferentiated and can undergo specialisation to produce cells that are adapted for specific functions in the body. Their uniqueness lies in the fact that these cells can self- renew and make copies of themselves, and they can also differentiate and give rise to specialised cells. The stem cells could either be embryonic in origin (derived from the blastocysts), or they could be adult cells, found in various body tissues. In adults, they repair and renew the body by giving rise to new tissues. When found in developing embryos, they develop into specialised cells such as the endoderm and ectoderm; and they also maintain organs such as blood and skin, which are regenerative.
Recent research has focused on the characteristics and isolation of stem cells due to their properties (self- renewal and ability to differentiate). They have the potential to be used in medical therapy to either treat or prevent certain diseases and conditions. For instance, they are used when carrying out bone marrow transplants, and research is underway on their use in treating diseases such as diabetes, Parkinson’s and Alzheimer’s, among others. For research to be successful, it is important to know their characteristics and how they can be used in medicine. It is also important that they are isolated before they can be applied in therapy.
Characteristics of Stem Cells
Stem cells are different and unique from all other body cells. One of their properties is that they can divide and renew themselves for a long time without differentiating (Rotter et al. 2008). According to Shahriyari and Komarova (2013), two processes are responsible for this. They can undergo asymmetric division to give rise to a stem and a non- stem cell. Symmetric division, which gives rise to either specialised or unspecialised stem cells can also take place. Self- renewal is an important property since it provides a continuous supply of the cells that are used throughout life. Research is currently underway to identify the factors that regulate proliferation and renewal in the stem cells.
Another unique characteristic of the cells is that they are unspecialized. They do not have any structures that will allow them to perform any specialised functions, which only occurs after differentiation. They can, however, give rise to specialised cells, such as skin or red blood cells. These cells cannot undergo mitosis to make copies when they are worn out or damaged. They soon become used up in the body and differentiation of stem cells is necessary to replace them and to keep the body functioning (Rotter et al. 2008). Internal signals (such as genes), and external signals (chemicals, molecules) are responsible for initiating the differentiation process. There is a need for more research to be carried out on the mechanisms that are responsible for their differentiation if stem cells are to be used in therapy. Understanding the signals responsible differentiation will be useful in growing cells and tissues that can be utilised for a particular purpose.
Isolation of Stem Cells
Stem cells could either be embryonic or adult cells. Embryonic cells are found in the blastocyst of embryos. These cells have the ability to give rise to any cell in the body and come up with an entirely viable individual. Adult stem cells are found in specialised tissues and organs. This cell can renew itself and to give rise to the cells unique to the particular tissue or organ. They repair and maintain the tissues in which they are found (Rotter et al. 2008).
The isolation of embryonic stem cells has presented many ethical challenges (Rotter et al. 2008). Such cells are thus derived from embryos fertilised in- vitro in the laboratory, and not from a woman’s body. Cells are harvested from a blastocyst 4- 5 days after fertilisation and they are transferred into a culture dish with nutrient medium. Most of the cells do not adapt to the culture, and do not survive. Those that survive will multiply rapidly in the medium. The dish is specially treated so that the stem cells will not continue dividing to give rise to differentiated cells. Once the cells multiply, they are removed and transferred into different plates. They undergo characterization to determine whether they exhibit the properties of the stem cells. Once this has been confirmed, they can now be used in experiments.
Adult (somatic) cells can be isolated from most organs and tissues in the body such as the brain, bone marrow, skin and blood, among others (Rotter et al. 2008). Their isolation is dependent on their type. For instance, some cells, such as those from the heart are rare, and only few can be isolated while those from blood are numerous and can be regularly isolated. Tissues have regions known as ‘stem cell niches’, occupied by the cells from which they can be isolated. They are few in the tissues, and their ability to divide is difficult.
Different protocols are used in the lab to culture stem cells, depending on the type and whether or not they are to be differentiated. Some of these methods as mentioned by Huang et al. (2015) include the positive and negative selection method; the enzymatic digestion approach and the frequent medium changes technique, among others. A culture dish with media that supports the growth of the cells and inhibits their differentiation is used. The medium has growth factors and molecules that encourage the cells to grow and multiply. Once they multiply, they undergo screening for gene expression among other tests that are used to confirm their identity. Once they are confirmed, they are preserved for future use.
The study of stem cells is a fascinating and rapidly growing field. They are found in the blastocyst, in the initial stages of an embryo (embryo stem cells) or the tissues of a fetus, a child or an adult (adult stem cells). Those from the embryo can differentiate into any cell while those found in the adults give rise to cells similar to those in the tissue in which they are located. These cells are thought to have the potential to treat and control life-threatening conditions such as diabetes, heart disease and Alzheimer’s, among others. This is due to their properties which can be used applied in medical science. Stem cells are unspecialized cells that can undergo differentiation to make them specialised. The mechanism controlling this is not completely understood, but it is necessary to replenish the body cells that are being worn out continuously. The ability of the cells to undergo self- renewal is also important since it provides a constant supply of the cells in particular organs and tissues. For these cells to be useful in medicine, scientists should have an understanding of their characteristics and how they can be isolated.
Rotter, N, Oder, J, Schlenke, P, Lindner, U, Bohrnsen, F, Kramer, J e. al. 2008, ‘Isolation and Characterization of Adult Stem Cells from Human Salivary Glands’, Stem Cells and Development, 17, pp 509- 518.
Shahriyari, L & Komarova NL 2013, ‘Symmetric vs. Asymmetric Stem Cell Divisions: An Adaptation against Cancer?’ PLoS ONE, vol. 8, no. 10, pp e76195.
Shuo, H, Liangliang, X, Yuxin, S, Tianyi, W, Kuixing, W & Gang, L 2015, ‘An Improved Protocol for Isolation and Culture of Mesenchymal Stem Cells from Mouse Bone Marrow, Journal of Orthopaedic Translation, vol. 3, no. 1, pp 26-33.
Tired of Guidelines or Lack Time to Work on Your Paper, Get Original Custom Research Paper Writing Service
Thecustomwriting.com research paper writing service has saved thousands of students from stressful college life. Writing a custom research paper may be challenging, considering it has to be plagiarism-free. And it is better not to do your project than to hand in plagiarized work or hurriedly complete it if you do not have time.
Academic integrity is so vital that you may get a suspension or an expulsion because of a copy-pasted work. Writing a custom research paper requires research and writing skills to produce original content. Here are essential things to know about getting the best and legit assignments help websites.
Perfection is vital
Every website will promise you that they produce high-quality work. However, you put your money for your end-of-semester paper only to get a pass. You must learn how to identify the best writing service before committing.
Thecustomwriting.com produces quality content at all times. Rather than a quality promise, quality assurance is what you should consider before hiring a research writer. Best writing services are reliable. You don't want to partner with a cheap research paper writing service that will deliver poorly written essays hours after the due date.
Quality writers are part of the best writing service. A company that has untrained writers will fail you. Before committing, ensure that the people who will write your paper are academicians and professionals. It would help if you had a writer who will be prompt to respond to your questions and follow instructions. Writers who do not fear to ask for clarification where they don't understand are the best for you.
Beware of Scammers Posing to Provide Custom Research Paper Writing Service
It may take time and effort to find a legit custom research paper writing service. Most of the websites claiming to offer writing service trades your paper with another student. For example, if you order your paper today to submit it next week, you may find that another student has already handed over the same document.
Your money is gone, you have no paper to submit, and the deadline is in two hours. You can only sit and cook up some stories for your lecturer. Otherwise, wait for a penalty or suspension.
Others will give you half-baked papers in the name of cheap essays. Apart from reselling your paper, some companies will offer you copy-pasted work. If you don't have tools such as Turnitin or Copyscape to check plagiarism, you may find yourself in the dean's office explaining why you copied your work from the internet word-to-word.
We offer one of the best research paper writing services in the USA and the U.K.
You won’t regret choosing Thecustomwriting.com to handle your research. Your project is an essential part of your academic work. It determines whether you will move on to the next semester or if your name will appear on the graduation list. Do not gamble your education by hiring any cheap essay writing website you find on the internet. Look for a custom research paper writing service reviews before commit.
Avoid scandals by hiring Thecustomwriting.com. Count yourself lucky if you are reading this article. You are in the right direction in finding the writing service for your paper. Though many websites could have frustrated you, Thecustomwriting.com is committed to providing you with reliable service for your paper.
Thecustomwriting.com offers quality services at affordable prices, and they deliver your work on time. They have native English writers that write your paper using the correct language.
Plagiarism Free Custom Research Paper Writing Service
Our writers understand the seriousness of writing plagiarized papers. Every institution has regulations that govern how a research project is conducted. Universities and colleges take plagiarism as gross misconduct. The best writing services are those that will deliver plagiarism-free papers.
Plagiarism involves, among others, copying a published work and delivering it to your lecturer as your own without acknowledging the sources.
Another way your work can be plagiarized is the failure to include the source of your content in a research paper. If you are using someone's thought, you need to include a reference and in-text citations to show that you are using another scholars' worker.
It's a gross mistake to write a five-page paper without a single source unless the paper's nature does not require you to rely on any sources. Here are some tips our writers use to avoid accidental plagiarism:
Cite direct quotes, statistics, and paraphrased content.
Ensure that all in-text citations are included in the biography and vice versa.
Directly quoting not more than 2% of the paper, if quoting is necessary (some papers are exempted from this rule, especially literature).
Stick to high authority, scholarly sources. Our writers will hardly paraphrase content from third party blogs and other questionable sites.
Consider Buying A Custom Research Paper from Thecustomwriting.Com
Consider hiring an expert essay writer if you are not sure about your capabilities. Referencing and citations can be challenging, especially if you try to do it for the first time. It's even harder when your lecturer asks you to use a hard referencing style. For example, Harvard requires you to include page numbers, dates, and the author's name in the text. If you have several papers with a strict deadline, you should consider hiring a custom research paper writing service to help you work on your essays.
However, ensure the website you want to hire offers legit writing service. A good website should at least charge for its services. You will find many websites willing to provide you with free services. No one is that idle to sit and write a paper for free. Sites that provide free or cheap services hooks you when you least expect.
Also, consider the price of writing a paper. Though cheap essays are of low quality, other sites may have inflated prices for their rate, making you needlessly break your bank.
Thecustomwriting.com understands the need for a fair and reasonable price for most students. We know that most students need service, but they do not have enough resources. We, therefore, offer quality service that you can afford.
Benefits of using custom research paper writing service
If this is your first time considering using a custom writing service, the first thing is to know why taking such an action is the best. Choosing Thecustomwriting.com ensures professional writers handle your paper. Letting a qualified person handle your project can boost your grade. You cannot afford to fail in the upcoming end-of-semester project. In any case, your progress to the next level will be determined by how well you perform in your essay.
Thecustomwriting.com ensures the timely delivery of your work. The good thing about legit essay writers is that they can write your essay within the shortest time possible, with one page taking up to one hour at most. It doesn't matter what time you want your work done: Thecustomwriting.com is always ready for a task.
We will give you a paper written explicitly for you. We will ensure that your paper is not delivered to someone else.
Come to think of this; if five of your classmates decide to order an essay for the same class, five writers will be assigned to work on different papers instead of paraphrasing one paper and sending it to five of you.
Frequently Asked Questions (FAQ)
It's our responsibility to ensure that someone from your field handles your paper. Our company has enough writers from every discipline. We provide only a research writer qualified in your subject to handle your paper. After placing an order, the first step is to screen the question and requirement and match it with the best writer. The less qualified writer has a college diploma, and they only handle high school papers. All other writers are bachelor, masters, and PhD degree holders.
We commit to quality content. We understand that failure to deliver quality service will result in the loss of clients. Therefore, we only hire qualified writers who have an in-depth understanding of your paper. Whether you want quantitative research done using Chi-square or qualitative research, Thecustomwriting.com’s writers will comfortably handle any discipline or type of paper. Besides, we offer research paper service from college to PhD. Therefore, we cannot afford to have unqualified writers. Our researchers take every instruction keenly when writing your essay.
There is nothing to worry about placing your order. Our platform has a simple, user-friendly interface that enables you to navigate to different functionalities with ease. We offer quality custom research paper writing services; thus, you don't have to worry about getting value for your money. Besides, you can track your order's progress. Our system progressively send you email notifications regarding every stage of your orders' progress; thus, you don't even have to log in to track down your order. You will also see the progress on the dashboard when you log in. Moreover, our support team will contact you when the writer needs any clarification.
Our system is designed in such a way that it allows you to communicate with your writer directly. We understand the need to clarify things yourself to the writer. Furthermore, our support team is available 24 hours to ensure that urgent matters are communicated swiftly with the writer.
The answer is yes. We value your efforts and trust to recommend us to your friends. We will offer you a discount on your next order if a client mentions your email when placing an order.
What guarantees should customers look for?
We have a written list of what we guarantee our clients in our terms. We guarantee the quality, confidentiality, free revision, original content, and timely delivery. We also guarantee money-back if, in the unlikely event, you are not happy with the quality of the paper.
What makes a reliable writing company?
It's easy to know a reputable company. First, they are transparent about their services. They offer multiple methods of communication and have qualified writers. Most importantly, they deliver your work on time, deliver original content, and honour what they have guaranteed.
Why should customers not opt for cheap essay writing services?
Cheap essay services will only waste your time. They have foreign writers who will produce plagiarized content full of grammar errors. You will waste your precious time waiting for a paper that you can't give your lecturer.
Is buying essays online safe?
It's safe to buy your essay if you take the right precaution. Before putting your money on a strange site, explore the website to see whether you will get customer reviews. They will help you make the right decision.
How do I hire someone to write an essay for me?
These are common questions with most clients. It's effortless to get a professional writer. The first step is to identify a custom research paper writing service that is legit and sign up. After that, they will guide you on how to place your order and get a writer. Some companies will allow you to choose a writer for yourself or choose a writer for you.
What types of writing services can I order online?
Our website offers a variety of legit essay services. We provide any academic assistance, including research projects, assignments, and admission letters. Visit our website to see what each service entails.
What benefits and additional features do Thecustomwriting.com services offer?
We offer several free services to our customers. We offer free revision, a discount on your first order, and free pages such as references and cover pages. Also, we have a quality control department that ensures that all papers are of high quality before delivering them to you.
Do websites maintain your privacy? Are orders secured?
Your privacy is our top priority. You will be recognized by your I.D. assigned to you after signup instead of your name. The only person who can access your account is you or anyone else you give your password. Your payment is through a third party. Therefore, your personal information will never reach our site without your consent.
What are the pros of ordering from custom writing services?
You get quality papers. We have writers with decades of experience delivering quality papers worth the client's money and much more. We understand your power to influence our progress. Your paper will be delivered on time and written by professional writers.
Hire a professional writer
Now that you know what to look for when considering the custom research paper writing services, it's time to try us. Sign up and get a discount on your first order. You don't have to worry about quality, timely delivery, and price. We know they are essential to you.